Protein name:
Fibronectin (FN) ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP, LGALS3BP and COL13A1 and COMP (By similarity). Interacts with TNR; interaction mediates inhibition of cell adhesion and neurite outgrowth. Interacts with FBLN7. Interacts with FST3.
Function:
Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.
Subcellular Location:
Secreted
extracellular space
extracellular matrix
Protein Attributes:
50:
MLRGPGPGRL | LLLAVLCLGT | SVRCTEAGKS | KRQAQQIVQP | QSPVAVSQSK |
100:
PGCFDNGKHY | QINQQWERTY | LGNALVCTCY | GGSRGFNCES | KPEPEETCFD |
150:
KYTGNTYKVG | DTYERPKDSM | IWDCTCIGAG | RGRISCTIAN | RCHEGGQSYK |
200:
IGDKWRRPHE | TGGYMLECLC | LGNGKGEWTC | KPIAEKCFDH | AAGTSYVVGE |
250:
TWEKPYQGWM | MVDCTCLGEG | NGRITCTSRN | RCNDQDTRTS | YRIGDTWSKK |
300:
DNRGNLLQCV | CTGNGRGEWK | CERHALQSAS | AGSGSFTDVR | TAIYQPQTHP |
350:
QPAPYGHCVT | DSGVVYSVGM | QWLKSQGNKQ | MLCTCLGNGV | SCQETAVTQT |
400:
YGGNSNGEPC | VLPFTYNGRT | FYSCTTEGRQ | DGHLWCSTTS | NYEQDQKYSF |
450:
CTDHAVLVQT | RGGNSNGALC | HFPFLYNNRN | YTDCTSEGRR | DNMKWCGTTQ |
500:
NYDADQKFGF | CPMAAHEEIC | TTNEGVMYRI | GDQWDKQHDL | GHMMRCTCVG |
550:
NGRGEWACIP | YSQLRDQCIV | DDITYNVNDT | FHKRHEEGHM | LNCTCFGQGR |
600:
GRWKCDPIDQ | CQDSETRTFY | QIGDSWEKFV | HGVRYQCYCY | GRGIGEWHCQ |
650:
PLQTYPGTTG | PVQVIITETP | SQPNSHPIQW | NAPEPSHITK | YILRWRPKTS |
700:
TGRWKEATIP | GHLNSYTIKG | LTPGVIYEGQ | LISIQQYGHR | EVTRFDFTTS |
750:
ASTPVTSNTV | TGETAPYSPV | VATSESVTEI | TASSFVVSWV | SASDTVSGFR |
800:
VEYELSEEGD | EPQYLDLPST | ATSVNIPDLL | PGRKYIVNVY | QISEEGKQSL |
850:
ILSTSQTTAP | DAPPDPTVDQ | VDDTSIVVRW | SRPQAPITGY | RIVYSPSVEG |
900:
SSTELNLPET | ANSVTLSDLQ | PGVQYNITIY | AVEENQESTP | VFIQQETTGT |
950:
PRSDNVPPPT | DLQFVELTDV | KVTIMWTPPD | SVVSGYRVEV | LPVSLPGEHG |
1000:
QRLPVNRNTF | AEITGLSPGV | TYLFKVFAVH | QGRESNPLTA | QQTTKLDAPT |
1050:
NLQFVNETDR | TVLVTWTPPR | ARIAGYRLTA | GLTRGGQPKQ | YNVGPLASKY |
1100:
PLRNLQPGSE | YTATLVAVKG | NQQSPKATGV | FTTLQPLRSI | PPYNTEVTET |
1150:
TIVITWTPAP | RIGFKLGVRP | SQGGEAPREV | TSDSGSIVVS | GLTPGVEYTY |
1200:
TIQVLRDGQE | RDAPIVNRVV | TPLSPPTNLH | LEANPDTGVL | TVSWERSTTP |
1250:
DITGYRITTT | PTNGQQGTSL | EEVVHADQSS | CTFENLNPGL | EYNVSVYTVK |
1300:
DDKESAPISD | TVVPEVPQLT | DLSFVDITDS | SIGLRWTPLN | SSTIIGYRIT |
1350:
VVAAGEGIPI | FEDFVDSSVG | YYTVTGLEPG | IDYDISVITL | INGGESAPTT |
1400:
LTQQTAVPPP | TDLRFTNIGP | DTMRVTWAPP | PSIELTNLLV | RYSPVKNEED |
1450:
VAELSISPSD | NAVVLTNLLP | GTEYLVSVSS | VYEQHESIPL | RGRQKTGLDS |
1500:
PTGFDSSDIT | ANSFTVHWVA | PRAPITGYII | RHHAEHSVGR | PRQDRVPPSR |
1550:
NSITLTNLNP | GTEYVVSIIA | VNGREESPPL | IGQQATVSDI | PRDLEVIAST |
1600:
PTSLLISWEP | PAVSVRYYRI | TYGETGGNSP | VQEFTVPGSK | STATINNIKP |
1650:
GADYTITLYA | VTGRGDSPAS | SKPVSINYKT | EIDKPSQMQV | TDVQDNSISV |
1700:
RWLPSTSPVT | GYRVTTTPKN | GLGPSKTKTA | SPDQTEMTIE | GLQPTVEYVV |
1750:
SVYAQNRNGE | SQPLVQTAVT | NIDRPKGLAF | TDVDVDSIKI | AWESPQGQVS |
1800:
RYRVTYSSPE | DGIRELFPAP | DGEDDTAELQ | GLRPGSEYTV | SVVALHDDME |
1850:
SQPLIGIQST | AIPAPTNLKL | SQVTPTSFTA | QWIAPSVQLT | GYRVRVNPKE |
1900:
KTGPMKEINL | SPDSSSVIVS | GLMVATKYEV | SVYALKDTLT | SRPAQGVITT |
1950:
LENVSPPRRA | RVTDATETTI | TISWRTKTET | ITGFQVDAIP | ANGQTPVQRS |
2000:
ISPDVRSYTI | TGLQPGTDYK | IHLYTLNDNA | RSSPVIIDAS | TAIDAPSNLR |
2050:
FLTTTPNSLL | VSWQAPRARI | TGYIIKYEKP | GSPPREVVPR | PRPGVTEATI |
2100:
TGLEPGTEYT | IYVIALKNNQ | KSEPLIGRKK | TDELPQLVTL | PHPNLHGPEI |
2150:
LDVPSTVQKT | PFITNPGYDT | ENGIQLPGTT | HQQPSVGQQM | IFEEHGFRRT |
2200:
TPPTAATPVR | LRPRPYLPNV | DEEVQIGHVP | RGDVDYHLYP | HVPGLNPNAS |
2250:
TGQEALSQTT | ISWTPFQESS | EYIISCQPVG | TDEEPLQFQV | PGTSTSATLT |
2300:
GLTRGVTYNI | IVEALQNQRR | HKVREEVVTV | GNAVSEGLNQ | PTDDSCFDPY |
2350:
TVSHYAIGEE | WERLSDAGFK | LTCQCLGFGS | GHFRCDSSKW | CHDNGVNYKI |
2400:
GEKWDRQGEN | GQRMSCTCLG | NGKGEFKCDP | HEATCYDDGK | TYHVGEQWQK |
2450:
EYLGAICSCT | CFGGQRGWRC | DNCRRPGAAE | PSPDGTTGHN | YNQYTQRYNQ |
2477:
RTNTNVNCPI | ECFMPLDVQA | DRDDSRE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Dog
Bovine
Chicken
Rabbit
Polyclonal Antibody for Mouse FN
Polyclonal Antibody for Mouse FN
Polyclonal Antibody for Mouse FN
Polyclonal Antibody for Mouse FN
Polyclonal Antibody for Mouse FN
Polyclonal Antibody for Mouse FN
Polyclonal Antibody for Mouse FN
Monoclonal Antibody for Mouse FN
Monoclonal Antibody for Mouse FN
Monoclonal Antibody for Mouse FN
Monoclonal Antibody for Mouse FN
Monoclonal Antibody for Mouse FN
Monoclonal Antibody for Mouse FN
Monoclonal Antibody for Mouse FN
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M.
,
Goodstadt L.
,
Hillier L.W.
,
Zody M.C.
,
Goldstein S.
,
She X.
,
Bult C.J.
,
Agarwala R.
,
Cherry J.L.
,
DiCuccio M.
,
Hlavina W.
,
Kapustin Y.
,
Meric P.
,
Maglott D.
,
Birtle Z.
,
Marques A.C.
,
Graves T.
,
Zhou S.
,
Teague B.
,
Potamousis K.
,
Churas C.
,
Place M.
,
Herschleb J.
,
Runnheim R.
,
Forrest D.
,
Amos-Landgraf J.
,
Schwartz D.C.
,
Cheng Z.
,
Lindblad-Toh K.
,
Eichler E.E.
,
Ponting C.P.
more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-920
strain :
FVB/N-3 .
tissue :
Mammary tumor .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-28
tissue :
Liver .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 562-834
strain :
NMRI .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 899-2376
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 2375-2477
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 2375-2477
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 2375-2477
tissue :
Kidney .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TRANSGLUTAMINATION AT GLN-35; GLN-36 AND GLN-48;MUTAGENESIS OF GLN-35; GLN-36 AND GLN-48
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DOWN-REGULATION BY GLUCOCORTICOIDS
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1006
strain :
C57BL/6 .
tissue :
Plasma .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FBLN7
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-528
strain :
C57BL/6 .
tissue :
Plasma .
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2475;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2475;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .
17.
"The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
Gundry R.L.
,
Raginski K.
,
Tarasova Y.
,
Tchernyshyov I.
,
Bausch-Fluck D.
,
Elliott S.T.
,
Boheler K.R.
,
Van Eyk J.E.
,
Wollscheid B.
Mol. Cell. Proteomics8:2555-2569(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-528; ASN-1001; ASN-1006; ASN-1290 AND ASN-2198
tissue :
Myoblast .
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2475;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic fibroblast .
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1006 AND ASN-1290
20.
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Cited for : FUNCTION
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Cited for : STRUCTURE BY NMR OF 1447-1630